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Front Immunol
. 2022 Dec 19;13:1038316.
doi: 10.3389/fimmu.2022.1038316. eCollection 2022.
Can vitamin D status influence seroconversion to SARS-COV2 vaccines?
Endrit Shahini 1 , Francesco Pesce 2 , Antonella Argentiero 3 , Antonio Giovanni Solimando 4
Affiliations
- PMID: 36601112
- PMCID: PMC9806423
- DOI: 10.3389/fimmu.2022.1038316
Abstract
Existing data indicate an association between vitamin D deficiency and increased severity of respiratory distress due to COVID-19 infection, especially in high-risk populations. To date, the effect of vitamin D on immunogenicity to SARS-CoV-2 vaccines has been investigated solely in young healthcare workers in a few studies, yielding conflicting findings, yet highlighting that the response to immunization is inversely related to age. Vitamin D status can potentially influence the antibody titers in people with a previous (or naïve) SARS-CoV-2 infection and vaccination, given its role in immune regulatory functions. From this standpoint, vitamin D supplementation can help reduce the risk of SARS-CoV-2 infection, COVID-19 severity/mortality and rebalance immunological function, particularly in subjects with vigorous T lymphocyte responses to COVID-19. However, more research is needed to establish a correlation between vitamin D status and the generation of protective serological responses to SARS-CoV-2 vaccination.
Keywords: COVID-19; antibodies; autoimmune disorders; coronavirus; pneumonia; serology; vitamin D.