Open Forum Infect Dis . A Systematic Review of COVID-19 Vaccine Antibody Responses in People With HIV

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Open Forum Infect Dis


. 2022 Nov 8;9(11):ofac579.
doi: 10.1093/ofid/ofac579. eCollection 2022 Nov.
A Systematic Review of COVID-19 Vaccine Antibody Responses in People With HIV


Helen M Chun ¹ , Kyle Milligan ^{1 2} , Elfriede Agyemang ¹ , Nathan Ford ³ , Ajay Rangaraj ³ , Shalini Desai ⁴ , Annelies Wilder-Smith ⁴ , Marco Vitoria ³ , Isaac Zulu ¹



Affiliations

• PMID: 36438620
• PMCID: PMC9685180
• DOI: 10.1093/ofid/ofac579

Abstract

HIV infection is a significant independent risk factor for severe coronavirus disease 2019 (COVID-19) disease and death. We summarize COVID-19 vaccine responses in people with HIV (PWH). A systematic literature review of studies from January 1, 2020, to March 31, 2022, of COVID-19 vaccine immunogenicity in PWH from multiple databases was performed. Twenty-eight studies from 12 countries were reviewed. While 22 (73%) studies reported high COVID-19 vaccine seroconversion rates in PWH, PWH with lower baseline CD4 counts, CD4/CD8 ratios, or higher baseline viral loads had lower seroconversion rates and immunologic titers. Data on vaccine-induced seroconversion in PWH are reassuring, but more research is needed to evaluate the durability of COVID-19 vaccine responses in PWH.

Keywords: COVID-19 vaccines; SARS-CoV-2 antibody; people with HIV; seroconversion.