Open Forum Infect Dis . Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers

[tetano]

Open Forum Infect Dis


. 2022 Oct 17;9(11):ofac544.
doi: 10.1093/ofid/ofac544. eCollection 2022 Nov.
Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers


M Ali Rai ¹ , Victoria Shi ¹ , Brooke D Kennedy ¹ , Jesse S Justement ¹ , Kathleen Gittens ² , Genevieve McCormack ¹ , Jana Blazkova ¹ , Susan Moir ¹ , Tae-Wook Chun ¹



Affiliations

• PMID: 36345429
• PMCID: PMC9619736
• DOI: 10.1093/ofid/ofac544

Abstract

We investigated effects of the severe acute respiratory syndrome coronavirus 2 (SARV-CoV-2) booster vaccination on human immunodeficiency virus (HIV) reservoir size, immune markers, and host immune responses in people with HIV receiving antiretroviral therapy. Our data suggest that the SARS-CoV-2 booster vaccine is not likely to replenish the persistent HIV reservoir nor provide an immunologic environment to facilitate active HIV expression/replication.

Keywords: HIV; HIV reservoirs; SARS-CoV-2; booster vaccine; immune markers and responses.