Open Forum Infect Dis
. 2022 Sep 12;9(9):ofac464.
doi: 10.1093/ofid/ofac464. eCollection 2022 Sep.
Risk of Long COVID in People Infected With Severe Acute Respiratory Syndrome Coronavirus 2 After 2 Doses of a Coronavirus Disease 2019 Vaccine: Community-Based, Matched Cohort Study
Daniel Ayoubkhani 1 2 , Matthew L Bosworth 1 , Sasha King 3 , Koen B Pouwels 4 5 , Myer Glickman 1 , Vahé Nafilyan 1 6 , Francesco Zaccardi 2 , Kamlesh Khunti 2 , Nisreen A Alwan 7 8 9 , A Sarah Walker 4 10
Affiliations
- PMID: 36168555
- PMCID: PMC9494414
- DOI: 10.1093/ofid/ofac464
Abstract
We investigated long COVID incidence by vaccination status in a random sample of UK adults from April 2020 to November 2021. Persistent symptoms were reported by 9.5% of 3090 breakthrough severe acute respiratory syndrome coronavirus 2 infections and 14.6% of unvaccinated controls (adjusted odds ratio, 0.59 [95% confidence interval, .50-.69]), emphasizing the need for public health initiatives to increase population-level vaccine uptake.
Keywords: COVID-19; coronavirus; long COVID; post-COVID condition; vaccination.