Intern Med . Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination

[tetano]

Intern Med


. 2022 Sep 13.
doi: 10.2169/internalmedicine.0404-22. Online ahead of print.
Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination


Masanobu Tanemoto ¹ , Ryosuke Oda ² , Yuichiro Toyama ² , Hirohiko Shizukawa ² , Kazuki Yokokawa ¹ , Taro Saito ¹ , Syuuichirou Suzuki ¹ , Akihiro Matsumura ¹ , Shin Hisahara ¹



Affiliations

• PMID: 36104199
• DOI: 10.2169/internalmedicine.0404-22

Abstract

A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably.

Keywords: SARS-CoV-2; anti-signal recognition particle antibody; immune-mediated necrotizing myopathy; myopathy; vaccine.