Expert Rev Vaccines . Vaccines against SARS-CoV-2 variants and future pandemics

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Expert Rev Vaccines


. 2022 Aug 4.
doi: 10.1080/14760584.2022.2110075. Online ahead of print.
Vaccines against SARS-CoV-2 variants and future pandemics


Taeyoung Park ¹ , Hyogyeong Hwang ¹ , Suhyeong Moon ¹ , Sang Gu Kang ¹ , Seunghyup Song ¹ , Young Hun Kim ¹ , Hanbi Kim ¹ , Eun-Ju Ko ² , Soon-Do Yoon ³ , Sang-Moo Kang ⁴ , Hye Suk Hwang ¹



Affiliations

• PMID: 35924678
• DOI: 10.1080/14760584.2022.2110075

Abstract

Introduction: Vaccination continues to be the most effective method for controlling COVID-19 infectious diseases. Nonetheless, SARS-CoV-2 variants continue to evolve and emerge, resulting in significant public concerns worldwide even after more than two years since the COVID-19 pandemic. It is significant to better understand how different COVID-19 vaccine platforms work, why SARS-CoV-2 variants continue to emerge, and what options for improving COVID-19 vaccines can be considered to fight against SARS-CoV-2 variants and future pandemics.
Area covered: Here, we reviewed the innate immune sensors in the recognition of SARS-CoV-2 virus, innate and adaptive immunity including neutralizing antibodies by different COVID-19 vaccines. Efficacy comparison of the several COVID-19 vaccine platforms approved to use in humans, concerns about SARS-CoV-2 variants and breakthrough infections, and the options for developing future COIVD-19 vaccines were also covered.
Expert opinion: Owing to the continuous emergence of novel pathogens and the re-emergence of variants, safer and more effective new vaccines are needed. This review is also aimed to provide the knowledge basis for the development of next-generation COVID-19 and pan-coronavirus vaccines to provide cross-protection against new SARS-CoV-2 variants and future coronavirus pandemics.

Keywords: SARS-CoV-2: ACE-2; TMPRSS-2; nucleic acid-based vaccine; universal vaccine.