J Int Med Res . Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report

[tetano]

J Int Med Res


. 2021 Nov;49(11):3000605211056783.
doi: 10.1177/03000605211056783.
Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report


Se Il Kim ¹ , **** Youl Seok ² , Jaehyuck Yi ³ , Jang Hyuk Cho ¹



Affiliations

• PMID: 34816739
• DOI: 10.1177/03000605211056783

Abstract

The ongoing global administration of vaccines for coronavirus disease 2019 (COVID-19) means that increasing numbers of patients are likely to present with post-vaccination complications. We describe the first reported case of neuralgic amyotrophy (NA) involving the lumbosacral plexus occurring after AstraZeneca COVID-19 vaccination. The patient presented with acute-onset leg paralysis following administration of the vaccine. Based on the clinical, electrodiagnostic, and radiologic findings, the patient was diagnosed with post-vaccination NA. We speculate that the COVID-19 vaccine elicited an immune-mediated inflammatory response to the injected antigen due to inflammatory immunity in a patient with predisposed susceptibility to NA.

Keywords: Coronavirus disease 2019; case report; complication; lumbosacral plexus; paralysis; vaccination.