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IgA nephropathy presenting as macroscopic hematuria in 2 pediatric patients after receiving the Pfizer COVID-19 vaccine

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  • IgA nephropathy presenting as macroscopic hematuria in 2 pediatric patients after receiving the Pfizer COVID-19 vaccine

    Christian Hanna, Loren P. Herrera Hernandez, Lihong Bu, Sarah Kizilbash, Lydia Najera, Michelle N. Rheault, Jan Czyzyk, Anne M. Kouri,
    IgA nephropathy presenting as macroscopic hematuria in 2 pediatric patients after receiving the Pfizer COVID-19 vaccine,
    Kidney International,
    Volume 100, Issue 3,
    2021,
    Pages 705-706,
    ISSN 0085-2538,
    https://doi.org/10.1016/j.kint.2021.06.032.
    (https://www.sciencedirect.com/scienc...85253821006669)

    To the editor:

    With great interest, we read the recent reports of IgA nephropathy (IgAN) flare-up presenting as macroscopic hematuria, following the second dose of coronavirus disease 2019 (COVID-19) vaccination in adult patients.1, 2, 3, 4 The US Food and Drug Administration granted an emergency use authorization for the Pfizer–BioNtech COVID-19 vaccination in December 2020 for individuals aged ≥16 years; the emergency use authorization was recently expanded to include children aged 12 to 15 years on May 10, 2021. Herein, we report 2 pediatric patients with IgAN presenting with macroscopic hematuria <24 hours after Pfizer COVID-19 vaccination. Neither patient had COVID-19 infection before vaccination nor any history of reactions to any vaccinations. See Table 1 for clinical information.


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