Cytotherapy . Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains

[tetano]

Cytotherapy


. 2021 Sep 2;S1465-3249(21)00741-6.
doi: 10.1016/j.jcyt.2021.07.006. Online ahead of print.
Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains


Maja Stanojevic ¹ , Ashley Geiger ¹ , Brita Ostermeier ² , Danielle Sohai ¹ , Christopher Lazarski ¹ , Haili Lang ¹ , Mariah Jensen-Wachspress ¹ , Kathleen Webber ¹ , Peter Burbelo ³ , Jeffrey Cohen ⁴ , Michael D Keller ¹ , Catherine M Bollard ⁵ , Conrad Russell Y Cruz ⁶



Affiliations

• PMID: 34483067
• DOI: 10.1016/j.jcyt.2021.07.006

Abstract

Although most studies describing coronavirus disease 2019 vaccine responses have focused on antibodies, there is increasing evidence that T cells play a critical role. Here the authors evaluated T-cell responses in seronegative donors before and after vaccination to define responses to the severe acute respiratory syndrome coronavirus 2 reference strain as well as to mutations in the variant strains Alpha/B.1.1.7 and Beta/B.1.351. The authors observed enhanced T-cell responses to reference and variant spike strains post-vaccination.

Keywords: COVID-19 variants; SARS-CoV-2; T-cell responses to coronavirus; vaccination.