J Med Virol . Biphasic anaphylaxis after exposure to the first dose of Pfizer-BioNTech COVID-19 mRNA vaccine

[tetano]

J Med Virol


. 2021 May 29.
doi: 10.1002/jmv.27109. Online ahead of print.
Biphasic anaphylaxis after exposure to the first dose of Pfizer-BioNTech COVID-19 mRNA vaccine


Christophe Abi Zeid Daou ¹ , Mohammad Ali Natout ¹ , Nadine El Hadi ¹



Affiliations

• PMID: 34050949
• DOI: 10.1002/jmv.27109

Abstract

Introduction: In the setting of a COVID-19 global pandemic and increased disease burden, vaccination has become one of the major solutions. With the increase in vaccination numbers worldwide it is important to stay vigilant to the potential side effects and life-threatening complications of such vaccines.
Case summary: 30 year old male with a biphasic allergic reaction post mRNA Pfizer-BioNTech COVID-19 vaccination.
Discussion: Several reports of allergic reactions have been cited in the literature after administration of the mRNA Pfizer-BioNTech COVID-19 vaccine. It is important to keep a high index of suspicion in severe anaphylactic cases as some patients may have recurrence of symptoms after discharge.
Conclusion: It is crucial to acknowledge the potential risk of anaphylaxis in select individuals and have the appropriate measures in place to deal with adverse events. In case of severe symptoms, the administration of epinephrine is advised to prevent the development of a delayed biphasic anaphylactic reaction. This article is protected by copyright. All rights reserved.

Keywords: Coronavirus < Virus classification; SARS coronavirus < Virus classification; Vaccines/Vaccine strains < Disease control.