J Inorg Biochem . Design and application of nanoparticles as vaccine adjuvants against human corona virus infection

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J Inorg Biochem


. 2021 Mar 29;219:111454.
doi: 10.1016/j.jinorgbio.2021.111454. Online ahead of print.
Design and application of nanoparticles as vaccine adjuvants against human corona virus infection


Lichun Mao ¹ , Ziwei Chen ¹ , Yaling Wang ² , Chunying Chen ³



Affiliations

• PMID: 33878530
• DOI: 10.1016/j.jinorgbio.2021.111454

Abstract

In recent years, some viruses have caused a grave crisis to global public health, especially the human coronavirus. A truly effective vaccine is therefore urgently needed. Vaccines should generally have two features: delivering antigens and modulating immunity. Adjuvants have an unshakable position in the battle against the virus. In addition to the perennial use of aluminium adjuvant, nanoparticles have become the developing adjuvant candidates due to their unique properties. Here we introduce several typical nanoparticles and their antivirus vaccine adjuvant applications. Finally, for the combating of the coronavirus, we propose several design points, hoping to provide ideas for the development of personalized vaccines and adjuvants and accelerate the clinical application of adjuvants.

Keywords: Human coronavirus; Nanoparticles; SARS-CoV-2; Vaccine adjuvants.