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Infect Genet Evol
. 2020 Jul 31;104490.
doi: 10.1016/j.meegid.2020.104490. Online ahead of print.
Genetic comparison among various coronavirus strains for the identification of potential vaccine targets of SARS-CoV2
Navpreet Kaur 1 , Rimaljot Singh 1 , Zahid Dar 2 , Rakesh Kumar Bijarnia 3 , Neelima Dhingra 2 , Tanzeer Kaur 4
Affiliations
- PMID: 32745811
- PMCID: PMC7395230
- DOI: 10.1016/j.meegid.2020.104490
Abstract
On-going pandemic pneumonia outbreak COVID-19 has raised an urgent public health issue worldwide impacting millions of people with a continuous increase in both morbidity and mortality. The causative agent of this disease is identified and named as SARS-CoV2 because of its genetic relatedness to SARS-CoV species that was responsible for the 2003 coronavirus outbreak. The immense spread of the disease in a very small period demands urgent development of therapeutic and prophylactic interventions for the treatment of SARS-CoV2 infected patients. A plethora of research is being conducted globally on this novel coronavirus strain to gain knowledge about its origin, evolutionary history, and phylogeny. This review is an effort to compare genetic similarities and diversifications among coronavirus strains, which can hint towards the susceptible antigen targets of SARS-CoV2 to come up with the potential therapeutic and prophylactic interventions for the prevention of this public threat.
Keywords: COVID-19; ER stress; Genomic comparison; SARS-CoV2; Target antigenic sites; Vaccine development.