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J Virol . SARS-CoV-2 Vaccines: 'Warp Speed' Needs Mind Melds Not Warped Minds

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  • J Virol . SARS-CoV-2 Vaccines: 'Warp Speed' Needs Mind Melds Not Warped Minds


    J Virol


    . 2020 Jun 26;JVI.01083-20.
    doi: 10.1128/JVI.01083-20. Online ahead of print.
    SARS-CoV-2 Vaccines: 'Warp Speed' Needs Mind Melds Not Warped Minds


    John P Moore 1 , P J Klasse 1



    Affiliations

    Abstract

    In this review, we address issues that relate to the rapid "Warp Speed" development of vaccines to counter the COVID-19 pandemic. We review the antibody response that is triggered by SARS-CoV-2 infection of humans, and how it may inform vaccine research. The isolation and properties of neutralizing monoclonal antibodies from COVID-19 patients provide additional information on what vaccines should try to elicit. The nature and longevity of the antibody response to coronaviruses are relevant to the potency and duration of vaccine-induced immunity. We summarize the immunogenicity of leading vaccine candidates tested to date in animals and humans, and discuss the outcome and interpretation of virus-challenge experiments in animals. By far the most immunogenic vaccine candidates for antibody responses are recombinant proteins, which are not included in the initial wave of "Warp Speed" immunogens. A substantial concern for SARS-CoV-2 vaccines is adverse events, which we review by considering what was seen in studies of SARS-CoV-1 and MERS-CoV vaccines. We conclude by outlining the possible outcomes of the "Warp Speed" vaccine program, which range from the hoped-for rapid success to a catastrophic adverse influence on vaccine uptake generally.



  • #2
    Here's a link to the full text.

    https://jvi.asm.org/content/jvi/earl...83-20.full.pdf
    Never forget Excalibur.
    “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed
    Avatar: Franz Marc, Liegender Hund im Schnee 1911 (My posts are not intended as advice or professional assessments of any kind.)

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