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NPJ Vaccines
. 2025 Jul 13;10(1):153.
doi: 10.1038/s41541-025-01203-z. Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
Guy de Bruyn 1 , Haritha Adhikarla 2 , Caroline K Brackett 3 , Yichen Jia 2 , Premkumar Lakshmanane 4 , Sarah V Mudrak 3 , Sheetal Sawant 3 , Donghui Zhang 5 , Roman M Chicz 6 , Saranya Sridhar 7 , Georgia D Tomaras # 3 , Kelly E Seaton # 3
Affiliations
We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.
. 2025 Jul 13;10(1):153.
doi: 10.1038/s41541-025-01203-z. Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
Guy de Bruyn 1 , Haritha Adhikarla 2 , Caroline K Brackett 3 , Yichen Jia 2 , Premkumar Lakshmanane 4 , Sarah V Mudrak 3 , Sheetal Sawant 3 , Donghui Zhang 5 , Roman M Chicz 6 , Saranya Sridhar 7 , Georgia D Tomaras # 3 , Kelly E Seaton # 3
Affiliations
- PMID: 40653502
- DOI: 10.1038/s41541-025-01203-z
We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.