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Open Forum Infect Dis
. 2023 May 17;10(5):ofad278.
doi: 10.1093/ofid/ofad278. eCollection 2023 May. Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy
Jana L Jacobs 1 , Ghady Haidar 1 , Asma Naqvi 1 , Kevin D McCormick 1 , Michele Sobolewski 1 , Benjamin R Treat 2 , Amy L Heaps 1 , Jordan Simpson 1 , Kailey Hughes Kramer 1 , Erin McCreary 1 , J Ryan Bariola 1 , Cynthia Klamar-Blain 1 , Bernard J C Macatangay 1 , Dimiter Dimitrov 1 , Wei Li 1 , Christopher C Marino 3 , Anastasios Raptis 3 , Rahil Sethi 4 , Uma Chandran 4 , Simon Barratt-Boyes 2 , Urvi M Parikh 1 , John W Mellors 1
Affiliations
Prolonged coronavirus disease 2019 may generate new viral variants. We report an immunocompromised patient treated with monoclonal antibodies who experienced rebound of viral RNA and emergence of an antibody-resistant (>1000-fold) variant containing 5 mutations in the spike gene. The mutant virus was isolated from respiratory secretions, suggesting the potential for secondary transmission.
. 2023 May 17;10(5):ofad278.
doi: 10.1093/ofid/ofad278. eCollection 2023 May. Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy
Jana L Jacobs 1 , Ghady Haidar 1 , Asma Naqvi 1 , Kevin D McCormick 1 , Michele Sobolewski 1 , Benjamin R Treat 2 , Amy L Heaps 1 , Jordan Simpson 1 , Kailey Hughes Kramer 1 , Erin McCreary 1 , J Ryan Bariola 1 , Cynthia Klamar-Blain 1 , Bernard J C Macatangay 1 , Dimiter Dimitrov 1 , Wei Li 1 , Christopher C Marino 3 , Anastasios Raptis 3 , Rahil Sethi 4 , Uma Chandran 4 , Simon Barratt-Boyes 2 , Urvi M Parikh 1 , John W Mellors 1
Affiliations
- PMID: 37265667
- PMCID: PMC10230564
- DOI: 10.1093/ofid/ofad278
Prolonged coronavirus disease 2019 may generate new viral variants. We report an immunocompromised patient treated with monoclonal antibodies who experienced rebound of viral RNA and emergence of an antibody-resistant (>1000-fold) variant containing 5 mutations in the spike gene. The mutant virus was isolated from respiratory secretions, suggesting the potential for secondary transmission.