Open Forum Infect Dis . Successful Treatment of Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Patients With Immunodeficiency With Extended Nirmatrelvir/Ritonavir: Case Series

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Open Forum Infect Dis


. 2023 Apr 6;10(4):ofad189.
doi: 10.1093/ofid/ofad189. eCollection 2023 Apr.
Successful Treatment of Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Patients With Immunodeficiency With Extended Nirmatrelvir/Ritonavir: Case Series


Madison Breeden ¹ , Samuel L Aitken ^{2 3} , Ji Hoon Baang ¹ , Misty Gravelin ⁴ , Daniel R Kaul ¹ , Adam S Lauring ¹ , Lindsay A Petty ¹ , Kevin S Gregg ¹



Affiliations

• PMID: 37089775
• PMCID: PMC10114524
• DOI: 10.1093/ofid/ofad189

Abstract

Immunocompromised patients with B-cell deficiencies are at risk for prolonged symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We describe 4 patients treated for B-cell malignancies with B-cell-depleting therapies who developed persistent SARS-CoV-2 infection and had resolution of symptoms following an extended course of nirmatrelvir/ritonavir.

Keywords: SARS-CoV-2; immunodeficiency; prolonged infection.