Int J Environ Res Public Health . Severe COVID-19 Complicated by Cerebral Venous Thrombosis in a Newborn Successfully Treated with Remdesivir, Glucocorticoids, and Hyperimmune Plasma

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Int J Environ Res Public Health


. 2021 Dec 15;18(24):13201.
doi: 10.3390/ijerph182413201.
Severe COVID-19 Complicated by Cerebral Venous Thrombosis in a Newborn Successfully Treated with Remdesivir, Glucocorticoids, and Hyperimmune Plasma


Laura Cursi ¹ , Francesca Ippolita Calo Carducci ¹ , Sara Chiurchiu ¹ , Lorenza Romani ¹ , Francesca Stoppa ² , Giulia Lucignani ³ , Cristina Russo ⁴ , Daniela Longo ³ , Carlo Federico Perno ⁴ , Corrado Cecchetti ² , Mary Haywood Lombardi ² , Patrizia D'Argenio ¹ , Laura Lancella ¹ , Stefania Bernardi ¹ , Paolo Rossi ¹



Affiliations

• PMID: 34948814
• DOI: 10.3390/ijerph182413201

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic, affecting all age groups with a wide spectrum of clinical presentation ranging from asymptomatic to severe interstitial pneumonia, hyperinflammation, and death. Children and infants generally show a mild course of the disease, although infants have been observed to have a higher risk of hospitalization and severe outcomes. Here, we report the case of a preterm infant with a severe form of SARS-CoV-2 infection complicated by cerebral venous thrombosis successfully treated with steroids, hyperimmune plasma, and remdesivir.

Keywords: COVID-19; SARS-CoV-2; cerebral thrombosis; newborn; remdesivir.