Open Forum Infect Dis . Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019 - FluTrackers News and Information

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Open Forum Infect Dis . Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019

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tetano

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Join Date: Dec 2009

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Open Forum Infect Dis . Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019

August 19, 2021, 03:01 AM

Open Forum Infect Dis

. 2021 Jul 16;8(8):ofab385.
doi: 10.1093/ofid/ofab385. eCollection 2021 Aug.
Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019

Emma D Bainbridge¹, Priscilla Y Hsue², Jonathan H Esensten³, Kara L Lynch³, Carolyn M Hendrickson⁴, Sarah B Doernberg¹, Monica Fung¹, Peter Chin-Hong¹, Clara Di Germanio⁵, Philip J Norris^{3 5}, Graham Simmons^{3 5}, David V Glidden⁶, Anne F Luetkemeyer⁷

Affiliations
PMID: 34405093

PMCID: PMC8344822

DOI: 10.1093/ofid/ofab385

Abstract

We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite selection of CCP with significantly higher total immunoglobulin G than recipients, neutralizing antibody levels did not differ between donor plasma and CCP recipients.

Keywords: COVID-19; SARS-CoV-2; antibody avidity; convalescent plasma; neutralizing antibody.

Tags: None

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