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J Clin Lab Anal
. 2021 May 5;e23789.
doi: 10.1002/jcla.23789. Online ahead of print.
The role and significance of angiotensin-converting enzyme 2 peptides in the treatment of coronavirus disease 2019
Yang Liu 1 , Huanzhong He 1 , Huilian Huang 2
Affiliations
- PMID: 33951227
- DOI: 10.1002/jcla.23789
Abstract
Since the end of 2019, coronavirus disease 2019 (COVID-19) caused by the novel coronavirus (2019-nCoV) posed a serious threat to human health and life. Therefore, the discovery of drugs that can effectively prevent and treat COVID-19 is urgently warranted. In this article, the role and significance of angiotensin-converting enzyme 2 in drug development and the treatment of COVID-19 are discussed. It was found that the binding of ACE2 to SARS-CoV-2-RBD involved two core regions (31st and 353rd lysine) and 20 amino acids of the ACE2 protein. The mutation of these amino acids could lead to a great change of the binding ability of ACE2 and SARS-CoV-2-RBD. This information was important for us to find more efficient ACE2 peptides to block the 2019-nCoV infection. So during this study, we summarized the role of ACE2 in the regulation of 2019-nCoV infection and stress, and hypothesized that the development and optimization of ACE2 peptide can effectively block 2019-nCoV infection and reliably treat the COVID-19.
Keywords: acute respiratory distress syndrome; angiotensin-converting enzyme 2; coronavirus disease 2019; drug prediction; novel coronavirus.