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Am J Med Sci
. 2021 Feb 25;S0002-9629(21)00072-0.
doi: 10.1016/j.amjms.2021.02.019. Online ahead of print.
Novel and Evolving Therapies for COVID-19 Related Pulmonary Complications
Piyush P Mehta 1 , Vividha S Dhapte-Pawar 2
Affiliations
- PMID: 33640363
- DOI: 10.1016/j.amjms.2021.02.019
Abstract
Coronaviruses disease 2019 (COVID-19) is the most crucial threat, the world has ever witnessed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of this disease pandemic. The World Health Organization has confirmed the continuing epidemic as a worldwide public health crisis. Presently, the research on COVID-19 is even in the primitive stage. Studies on unveiling the natural route of COVID-19 infection and related pathophysiology, the biology of pulmonary airways pose a more rational restorative approach in the management of COVID-19. Thus, based on the existing facts, we methodically reviewed the efforts put forth by various research institutes, pharmaceutical companies and biotechnology firms in pulmonary delivery to prevent and control the COVID-19. This article would be valuable for the healthcare community, which is efficiently dealing with the SARS-CoV-2 crisis.
Keywords: COVID-19; drug repurposing and disposable medical devices; dry powders; inhaled vaccine; intranasal drug delivery; pulmonary therapy.