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2 February 2021
From today, baricitinib – an anti-inflammatory treatment for rheumatoid arthritis– will be investigated in the Randomised Evaluation of COVid-19 thERapY (RECOVERY) trial. This is the world’s largest clinical trial of treatments for patients hospitalised with COVID-19, taking place in 177 hospital sites across the UK and with over 33,000 patients recruited so far.
... As an anti-inflammatory, baricitinib may block the signalling activity of cytokine molecules which contribute to the hyper-inflammatory state seen in severe COVID-19. It is thought that baricitinib may act also have some anti-viral activity.
There is some clinical trial evidence that baricitinib may be beneficial against COVID-19. The Adaptive Covid-19 Treatment Trial (ACTT-2), a randomised clinical trial involving over 1,000 patients with moderate to severe COVID-19, tested baricitinib with remdesivir against remdesivir with a placebo. This concluded that baricitinib with remdesivir was superior to remdesivir alone in reducing recovery time and accelerating improvement in clinical status among COVID-19 patients, particularly those receiving oxygen or non-invasive ventilation.
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From today, baricitinib – an anti-inflammatory treatment for rheumatoid arthritis– will be investigated in the Randomised Evaluation of COVid-19 thERapY (RECOVERY) trial. This is the world’s largest clinical trial of treatments for patients hospitalised with COVID-19, taking place in 177 hospital sites across the UK and with over 33,000 patients recruited so far.
... As an anti-inflammatory, baricitinib may block the signalling activity of cytokine molecules which contribute to the hyper-inflammatory state seen in severe COVID-19. It is thought that baricitinib may act also have some anti-viral activity.
There is some clinical trial evidence that baricitinib may be beneficial against COVID-19. The Adaptive Covid-19 Treatment Trial (ACTT-2), a randomised clinical trial involving over 1,000 patients with moderate to severe COVID-19, tested baricitinib with remdesivir against remdesivir with a placebo. This concluded that baricitinib with remdesivir was superior to remdesivir alone in reducing recovery time and accelerating improvement in clinical status among COVID-19 patients, particularly those receiving oxygen or non-invasive ventilation.
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