J Infect Dis . Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic

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J Infect Dis


. 2020 Dec 24;jiaa789.
doi: 10.1093/infdis/jiaa789. Online ahead of print.
Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic


Jeffrey R Strich ^{1 2} , Marcos J Ramos-Benitez ¹ , Davide Randazzo ³ , Sydney R Stein ¹ , Ashley Babyak ¹ , Richard T Davey ⁴ , Anthony F Suffredini ¹ , Richard W Childs ^{2 5} , Daniel S Chertow ^{1 2 4}



Affiliations

• PMID: 33367731
• DOI: 10.1093/infdis/jiaa789

Abstract

Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in Coronavirus Disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrate that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.

Keywords: COVID-19; Neutrophil extracellular traps; fostamatinib; immunothrombosis.