Curr Drug Targets . A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2

[tetano]

Curr Drug Targets


. 2020 Dec 28.
doi: 10.2174/1389450121666201228122845. Online ahead of print.
A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2


Mohana Das ¹ , Manish Kumar ¹ , Abhishek Jha ¹ , Madhukiran D R ¹ , Kanchan Bharti ¹ , Shomedeep Mondal ¹ , Brahmeshwar Mishra ¹



Affiliations

• PMID: 33371846
• DOI: 10.2174/1389450121666201228122845

Abstract

Coronaviruses are a group of known RNA virus which primarily infects the respiratory tract, and also neurological, enteric, and hepatic systems. Endemic outbreaks of Middle East Coronavirus Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) have been observed in recent decades. A new strain named the SARS CoV-2(COVID-19) virus has now spread across the globe. SARS-CoV-2 is highly communicable and has culminated in a massive pandemic of COVID-19. Currently, no successful treatment is available. Therefore, an urgent need is there for new screening models that can aid in identifying the drugs with potential activity against COVID-19. The current review aims to discuss various in-silico, in-vitro and in-vivo screening methods, that can potentially be used to expedite the discovery of new active therapeutic candidates and vaccines, drug targets, and repurposing the commercially available drugs against COVID-19 for the effective management of the infection and thereby controlling this pandemic. Further, the current status of drugs and vaccines under clinical investigation has been summarized.

Keywords: COVID-19; Corona Virus; SARS-CoV.1. Introduction; Screening Models.