Front Immunol . Perspective: The Potential Effects of Naringenin in COVID-19

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Front Immunol


. 2020 Sep 25;11:570919.
doi: 10.3389/fimmu.2020.570919. eCollection 2020.
Perspective: The Potential Effects of Naringenin in COVID-19


Ricardo Wesley Alberca ¹ , Franciane Mouradian Emidio Teixeira ² , Danielle Rosa Beserra ¹ , Emily Araujo de Oliveira ¹ , Milena Mary de Souza Andrade ¹ , Anna Julia Pietrobon ² , Maria Notomi Sato ¹



Affiliations

• PMID: 33101291
• PMCID: PMC7546806
• DOI: 10.3389/fimmu.2020.570919

Free PMC article

Abstract

Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization in March 2020. Severe COVID-19 cases develop severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. The higher risk group includes the elderly and subjects with pre-existing chronic illnesses such as obesity, hypertension, and diabetes. To date, no specific treatment or vaccine is available for COVID-19. Among many compounds, naringenin (NAR) a flavonoid present in citrus fruits has been investigated for antiviral and anti-inflammatory properties like reducing viral replication and cytokine production. In this perspective, we summarize NAR potential anti-inflammatory role in COVID-19 associated risk factors and SARS-CoV-2 infection.

Keywords: ACE2; COVID-19; SARS-CoV-2; TNF; anti-inflammatory; antiviral; naringenin.