PLoS Pathog . Exploring links between vitamin D deficiency and COVID-19

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PLoS Pathog


. 2020 Sep 18;16(9):e1008874.
doi: 10.1371/journal.ppat.1008874. eCollection 2020 Sep.
Exploring links between vitamin D deficiency and COVID-19


Mradul Mohan ¹ , Jerin Jose Cherian ² , Amit Sharma ^{1 3}



Affiliations

• PMID: 32946517
• DOI: 10.1371/journal.ppat.1008874

Abstract

Coronavirus Disease 2019 (COVID-19) pandemic remains a major public health threat in most countries. The causative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to acute respiratory distress syndrome and result in mortality in COVID-19 patients. Vitamin D is an immunomodulator hormone with established effectiveness against various upper respiratory infections. Vitamin D can stall hyper-inflammatory responses and expedite healing process of the affected areas, primarily in the lung tissue. Thus, there are ecological and mechanistic reasons to promote exploration of vitamin D action in COVID-19 patients. As no curative drugs are available currently for COVID-19, we feel that the potential of vitamin D to alter the course of disease severity needs to be investigated. Clinical studies may be undertaken to address the value of vitamin D supplementation in deficient, high-risk COVID-19 patients.