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Clin Infect Dis . Evaluating the Efficacy of Therapies in COVID-19 Patients

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  • Clin Infect Dis . Evaluating the Efficacy of Therapies in COVID-19 Patients


    Clin Infect Dis


    . 2020 Aug 21;ciaa1231.
    doi: 10.1093/cid/ciaa1231. Online ahead of print.
    Evaluating the Efficacy of Therapies in COVID-19 Patients


    Dan-Yu Lin 1 , Donglin Zeng 1 , Joseph J Eron 1



    Affiliations

    Abstract

    There is a proliferation of clinical trials worldwide to find effective therapies for patients diagnosed with novel coronavirus disease-2019 (COVID-19). The endpoints that are currently used to evaluate the efficacy of therapeutic agents against COVID-19 are focused on clinical status at a particular day or on time to a specific change of clinical status. To provide a full picture of the clinical course of a patient and make complete use of available data, we consider the trajectory of clinical status over the entire follow-up period. We also show how to combine the evidence of treatment effects on the occurrences of various clinical events. We compare the proposed and existing endpoints through extensive simulation studies. Finally, we provide guidelines on establishing the benefits of treatments.


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