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J Exp Med . Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19
J Exp Med . Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19
J Exp Med
. 2020 Sep 7;217(9):e20201342.
doi: 10.1084/jem.20201342. Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19
An exacerbated and unbalanced immune response may account for the severity of COVID-19, the disease caused by the novel severe acute respiratory syndrome (SARS) coronavirus 2, SARS-CoV-2. In this Viewpoint, we summarize recent evidence for the role of neutrophils in the pathogenesis of COVID-19 and propose CXCR2 inhibition as a promising treatment option to block neutrophil recruitment and activation.
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