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J Infect Dev Ctries
. 2025 Nov 30;19(11):1606-1614.
doi: 10.3855/jidc.20584. Comparing the clinical outcomes of Remdesivir and Interferon beta-1a in hospitalized COVID-19 patients: A cross-sectional retrospective single-center study
Mehrdad Asgari 1 , Abolfazl Kousha 2 , Mohammad Ebrahim Ghaffari 3 , Tofigh Yaghubi Kalurazi 4 , Arash Zaminy 5
Affiliations
Introduction: The effectiveness of remdesivir (RDV) and interferon beta-1a (IFNβ-1a) was assessed and compared in patients hospitalized with coronavirus disease of 2019 (COVID-19).
Methodology: A total of 162 hospitalized COVID-19 patients were divided into two groups: the RDV group and the IFNβ-1a group. Through laboratory tests and a physical examination, the patient's clinical condition was evaluated.
Results: RDV and IFNβ-1a treatments significantly decreased fever, cough, shortness of breath, and weakness in COVID-19 patients (All p < 0.001). RDV treatment significantly decreased shortness of breath, erythrocyte sedimentation rate (ESR), and creatinine, relative to IFNβ-1a treatment (p < 0.03, p = 0.001, and p < 0.004, respectively). RDV treatment significantly decreased Lactate Dehydrogenase (LDH) in COVID-19 patients (p = 0.006). The mean time of hospitalization was 8.9 days in the RDV group and 8.2 days in the IFNβ-1a group. There was no statistical difference between the two groups. The IFNβ-1a group had a considerably lower rate of intensive care unit (ICU) admission than the RDV group (p = 0.006).
Conclusions: No difference in clinical outcomes was found between RDV and IFNβ-1a treatments. RDV was more effective than IFNβ-1a in moderating the inflammatory response in COVID-19 patients by reducing LDH and ESR. The IFNβ-1a group had a considerably lower rate of ICU admission than the RDV group.
Keywords: COVID-19; Remdesivir; hospitalized patients; interferon beta-1a.
. 2025 Nov 30;19(11):1606-1614.
doi: 10.3855/jidc.20584. Comparing the clinical outcomes of Remdesivir and Interferon beta-1a in hospitalized COVID-19 patients: A cross-sectional retrospective single-center study
Mehrdad Asgari 1 , Abolfazl Kousha 2 , Mohammad Ebrahim Ghaffari 3 , Tofigh Yaghubi Kalurazi 4 , Arash Zaminy 5
Affiliations
- PMID: 41358767
- DOI: 10.3855/jidc.20584
Introduction: The effectiveness of remdesivir (RDV) and interferon beta-1a (IFNβ-1a) was assessed and compared in patients hospitalized with coronavirus disease of 2019 (COVID-19).
Methodology: A total of 162 hospitalized COVID-19 patients were divided into two groups: the RDV group and the IFNβ-1a group. Through laboratory tests and a physical examination, the patient's clinical condition was evaluated.
Results: RDV and IFNβ-1a treatments significantly decreased fever, cough, shortness of breath, and weakness in COVID-19 patients (All p < 0.001). RDV treatment significantly decreased shortness of breath, erythrocyte sedimentation rate (ESR), and creatinine, relative to IFNβ-1a treatment (p < 0.03, p = 0.001, and p < 0.004, respectively). RDV treatment significantly decreased Lactate Dehydrogenase (LDH) in COVID-19 patients (p = 0.006). The mean time of hospitalization was 8.9 days in the RDV group and 8.2 days in the IFNβ-1a group. There was no statistical difference between the two groups. The IFNβ-1a group had a considerably lower rate of intensive care unit (ICU) admission than the RDV group (p = 0.006).
Conclusions: No difference in clinical outcomes was found between RDV and IFNβ-1a treatments. RDV was more effective than IFNβ-1a in moderating the inflammatory response in COVID-19 patients by reducing LDH and ESR. The IFNβ-1a group had a considerably lower rate of ICU admission than the RDV group.
Keywords: COVID-19; Remdesivir; hospitalized patients; interferon beta-1a.