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Annals of internal medicine
High-Dose N-Acetylcysteine Therapy for Novel H1N1 Influenza Pneumonia
1. Kang Yiu Lai, MRCP;
2. Wing Yiu Ng, MRCP;
3. Pik Kei Osburga Chan, MRCP;
4. Kit Fai Wong, MD, MRCP; and
5. Fanny Cheng, MRCP
1.
From Queen Elizabeth Hospital, Kowloon, Hong Kong.
Background: High-dose N-acetylcysteine synergizes with oseltamivir to protect mice from fatal influenza infection.
Objective: To show the potential role of N-acetylcysteine in the treatment of novel H1N1 influenza pneumonia in a dose used to treat acetaminophen overdose.
Case Report: On 15 July 2009, we admitted a previously healthy woman to the intensive care unit in a Hong Kong hospital for novel H1N1 human swine influenza (H1N1) pneumonia with septic shock and type 1 respiratory failure. She was 48 years of age, was not obese, and was a long-term smoker. She required pressure-controlled ventilation with 100% oxygen, 18-cm H2O positive end-expiratory pressure, and inhaled nitric oxide at 20 ppm to maintain blood oxygen saturation above 90%. We started treatment with norepinephrine infusion and physiologic doses of hydrocortisone for septic shock. Test ?
High-Dose N-Acetylcysteine Therapy for Novel H1N1 Influenza Pneumonia
1. Kang Yiu Lai, MRCP;
2. Wing Yiu Ng, MRCP;
3. Pik Kei Osburga Chan, MRCP;
4. Kit Fai Wong, MD, MRCP; and
5. Fanny Cheng, MRCP
1.
From Queen Elizabeth Hospital, Kowloon, Hong Kong.
Background: High-dose N-acetylcysteine synergizes with oseltamivir to protect mice from fatal influenza infection.
Objective: To show the potential role of N-acetylcysteine in the treatment of novel H1N1 influenza pneumonia in a dose used to treat acetaminophen overdose.
Case Report: On 15 July 2009, we admitted a previously healthy woman to the intensive care unit in a Hong Kong hospital for novel H1N1 human swine influenza (H1N1) pneumonia with septic shock and type 1 respiratory failure. She was 48 years of age, was not obese, and was a long-term smoker. She required pressure-controlled ventilation with 100% oxygen, 18-cm H2O positive end-expiratory pressure, and inhaled nitric oxide at 20 ppm to maintain blood oxygen saturation above 90%. We started treatment with norepinephrine infusion and physiologic doses of hydrocortisone for septic shock. Test ?
