Microbes Infect . Influenza Virus Glycoprotein-reactive Human Monoclonal Antibodies

[tetano]

Microbes Infect


. 2020 Jun 19;S1286-4579(20)30120-9.
doi: 10.1016/j.micinf.2020.06.003. Online ahead of print.
Influenza Virus Glycoprotein-reactive Human Monoclonal Antibodies


Yanbai Li ¹ , Lili Wang ² , Helong Si ¹ , Zhengsen Yu ¹ , Shijun Tian ¹ , Rong Xiang ¹ , Xiaoqian Deng ¹ , Ruiying Liang ¹ , Shibo Jiang ³ , Fei Yu ⁴



Affiliations

• PMID: 32569735
• PMCID: PMC7303604
• DOI: 10.1016/j.micinf.2020.06.003

Free PMC article

Abstract

Influenza continues to be a significant public health challenge. Two glycoproteins on the surface of influenza virus, hemagglutinin and neuraminidase, play a prominent role in the process of influenza virus infection and release. Monoclonal antibodies targeting glycoproteins can effectively prevent the spread of the virus. In this review, we summarized currently reported human mAbs targeting glycoproteins of influenza A and B viruses.

Keywords: glycoproteins; hemagglutinin; influenza A virus; influenza B virus; monoclonal antibodies; neuraminidase.



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