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Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection

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  • Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection

    Chin J Nat Med. 2019 Sep;17(9):650-662. doi: 10.1016/S1875-5364(19)30079-2.
    Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection.

    Geng ZK1, Li YQ1, Cui QH2, DU RK2, Tian JZ3.
    Author information

    1 School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. 2 School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; Collaborative Innovation Center for Antiviral Traditional Chinese Medicine, Jinan 250355, China. 3 School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; Collaborative Innovation Center for Antiviral Traditional Chinese Medicine, Jinan 250355, China. Electronic address: tianjingzhen@163.com.

    Abstract

    Ge Gen Decoction (GGD), a Traditional Chinese Medicine prescription, is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus (IAV) infection. However, the underlying mechanism of GGD against IAV infection remains unclear. In this study, we found that GGD had moderate anti-IAV activity in vitro. GGD was more effective when given before the viral infection and targeted the viral attachment and replication stages rather than the internalization stage. In vivo, GGD treatment reduced thevirus titers of lung tissue significantly and improved the survival rate, lung index, and pulmonary histopathological changes in H1N1-infected mice. We observed the changes in several key immuno-related indexes in GGD administrated H1N1-infected mice with anti-IAV drug oseltamivir phosphate as the control. GGD treatment decreased the expression of TNF-α and improved Th1/Th2 immune balance to reduce the excessive immune response in H1N1-infected mice. Besides, the expression of the toll-like receptor 7 signaling pathway in H1N1-infected mice decreased after GGD treatment. Our results showed that GGD has anti-IAV activity and can modulate the immune system to relieve lung inflammation.
    Copyright 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.


    KEYWORDS:

    Antiviral; Ge Gen Decoction; H1N1; Immune regulation; Traditional Chinese Medicine (TCM)

    PMID: 31526500 DOI: 10.1016/S1875-5364(19)30079-2
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