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Antiviral and Virucidal Activities of Umesu Phenolics on Influenza Viruses

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  • Antiviral and Virucidal Activities of Umesu Phenolics on Influenza Viruses

    Jpn J Infect Dis. 2019 Aug 30. doi: 10.7883/yoken.JJID.2018.522. [Epub ahead of print]
    Antiviral and Virucidal Activities of Umesu Phenolics on Influenza Viruses.

    Ikeda K1, Nishide M2, Tsujimoto K2,3, Nagashima S2,4, Kuwahara T4, Mitani T5, Koyama AH2,3,4.
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    1 School of Health and Nursing Science, Wakayama Medical University. 2 Wakayama Shin-Ai Women's Junior College. 3 School of Medicine, Wakayama Medical University. 4 Department of Molecular Microbiology, Faculty of Medicine, Kagawa University. 5 Center of Regional Revitalization, Research Center for Food and Agriculture, Wakayama University.


    Umesu phenolics were purified from the salt-extracts of Japanese apricot (Nanko-mume cultivar of Prunus mume Sieb. et Zucc.). Characterization of umesu phenolics revealed that they inhibited the multiplication of influenza virus and several other RNA and DNA viruses, when added to the culture media of the infected cells. In addition to these antiviral activities, the phenolics significantly decreased a plating efficiency of influenza virus, if present in the virus inoculum. More drastic effects were observed in virucidal activity; the infectivity of several strains of influenza viruses decreased less than 0.001 when they were incubated with 4 mg/ml phenolics at 30℃ for 5 min. The virucidal activity of phenolics was found to be more remarkable in acidic conditions, but the activity was not merely a result of the acidity of the phenolics. These results clearly indicate the antiviral and virucidal activities of the umesu phenolics against influenza viruses and suggest their potential pharmacological usefulness as a disinfectant or preventive medicine against superficial infections, such as the respiratory infection.


    Antiviral; Prunus mume; Virucidal; influenza virus; phenolics

    PMID: 31474696 DOI: 10.7883/yoken.JJID.2018.522
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