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Infect Genet Evol. 2019 Aug 19:104009. doi: 10.1016/j.meegid.2019.104009. [Epub ahead of print]
FoxOs could play an important role during influenza A viruses infection via microarray analysis based on GEO database.
Wu H1, Zhang R2, Fan X3, Lian Z4, Hu Y5.
Author information
1 Beijing Key Laboratory of Animal Genetic Improvement, Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, No.2 Yuanmingyuan West Rd, Haidian, Beijing 100193, PR China. Electronic address: b20153040147@cau.edu.cn. 2 Beijing Key Laboratory of Animal Genetic Improvement, Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, No.2 Yuanmingyuan West Rd, Haidian, Beijing 100193, PR China. Electronic address: zr123@cau.edu.cn. 3 National Surveillance and Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center, No. 369 Nanjing Rd, Shibei, Qingdao 266032, Shandong, PR China. Electronic address: fanxiaoxu@cahec.cn. 4 Beijing Key Laboratory of Animal Genetic Improvement, Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, No.2 Yuanmingyuan West Rd, Haidian, Beijing 100193, PR China. Electronic address: lianzhx@cau.edu.cn. 5 Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Rd, Haidian, Beijing 100193, PR China. Electronic address: huyx@cau.edu.cn.
Abstract
Influenza is a highly contagious respiratory illness caused by influenza A viruses (IAVs). The response and reaction from the host vary due to different subtypes. In this study, we identified the global transcriptomics of HUVEC (human umbilical vein endothelial cells) and macrophage cells after infection of H5N1 and H1N1 strains using microarray data from Gene Expression Omnibus (GEO), respectively. Our data showed that influenza A viruses (IAVs) could induce more global profound transcriptomics in HUVEC than macrophage cells. H5N1 infection led to much more rigorous apoptosis than H1N1 did in macrophage cells. Our data is consistent with the idea that by maintaining normal levels of FoxO1 could be maintained, the pro-apoptotic effects of IAV virus infection could be reduced. Anti-inflammatory and anti-apoptosis responses could be manipulated via FoxOs in response to IAVs infection, indicating that FoxOs could function as candidate target for the treatment of IAVs infection. Our result thus provides new insight for the future strategy of anti-IAVs therapy.
Copyright ? 2018. Published by Elsevier B.V.
KEYWORDS:
Apoptosis; FoxOs; HUVEC; Influenza A; Macrophage cells
PMID: 31437558 DOI: 10.1016/j.meegid.2019.104009
FoxOs could play an important role during influenza A viruses infection via microarray analysis based on GEO database.
Wu H1, Zhang R2, Fan X3, Lian Z4, Hu Y5.
Author information
1 Beijing Key Laboratory of Animal Genetic Improvement, Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, No.2 Yuanmingyuan West Rd, Haidian, Beijing 100193, PR China. Electronic address: b20153040147@cau.edu.cn. 2 Beijing Key Laboratory of Animal Genetic Improvement, Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, No.2 Yuanmingyuan West Rd, Haidian, Beijing 100193, PR China. Electronic address: zr123@cau.edu.cn. 3 National Surveillance and Research Center for Exotic Animal Diseases, China Animal Health and Epidemiology Center, No. 369 Nanjing Rd, Shibei, Qingdao 266032, Shandong, PR China. Electronic address: fanxiaoxu@cahec.cn. 4 Beijing Key Laboratory of Animal Genetic Improvement, Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, No.2 Yuanmingyuan West Rd, Haidian, Beijing 100193, PR China. Electronic address: lianzhx@cau.edu.cn. 5 Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Rd, Haidian, Beijing 100193, PR China. Electronic address: huyx@cau.edu.cn.
Abstract
Influenza is a highly contagious respiratory illness caused by influenza A viruses (IAVs). The response and reaction from the host vary due to different subtypes. In this study, we identified the global transcriptomics of HUVEC (human umbilical vein endothelial cells) and macrophage cells after infection of H5N1 and H1N1 strains using microarray data from Gene Expression Omnibus (GEO), respectively. Our data showed that influenza A viruses (IAVs) could induce more global profound transcriptomics in HUVEC than macrophage cells. H5N1 infection led to much more rigorous apoptosis than H1N1 did in macrophage cells. Our data is consistent with the idea that by maintaining normal levels of FoxO1 could be maintained, the pro-apoptotic effects of IAV virus infection could be reduced. Anti-inflammatory and anti-apoptosis responses could be manipulated via FoxOs in response to IAVs infection, indicating that FoxOs could function as candidate target for the treatment of IAVs infection. Our result thus provides new insight for the future strategy of anti-IAVs therapy.
Copyright ? 2018. Published by Elsevier B.V.
KEYWORDS:
Apoptosis; FoxOs; HUVEC; Influenza A; Macrophage cells
PMID: 31437558 DOI: 10.1016/j.meegid.2019.104009