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J Dairy Sci. 2018 Oct 10. pii: S0022-0302(18)30962-7. doi: 10.3168/jds.2018-15137. [Epub ahead of print]
Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice.
Kim DH1, Chung WC2, Chun SH1, Han JH2, Song MJ3, Lee KW4.
Author information
Abstract
Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.
KEYWORDS:
anti-influenza; heat-treated Lactobacillus plantarum nF1; natural killer cell activity; yogurt
PMID: 30316596 DOI: 10.3168/jds.2018-15137
Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice.
Kim DH1, Chung WC2, Chun SH1, Han JH2, Song MJ3, Lee KW4.
Author information
Abstract
Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.
KEYWORDS:
anti-influenza; heat-treated Lactobacillus plantarum nF1; natural killer cell activity; yogurt
PMID: 30316596 DOI: 10.3168/jds.2018-15137