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Front Microbiol. 2018 Sep 27;9:2338. doi: 10.3389/fmicb.2018.02338. eCollection 2018.
Aloe Polysaccharides Inhibit Influenza A Virus Infection-A Promising Natural Anti-flu Drug.
Sun Z1, Yu C2, Wang W3, Yu G1, Zhang T1, Zhang L2, Zhang J1, Wei K2.
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Abstract
Influenza A virus causes periodic outbreaks and seriously threatens human health. The drug-resistant mutants have shown an epidemic trend because of the abuse of chemical drugs. Aloe polysaccharides (APS) extracted from Aloe vera leaves have evident effects on the therapy of virus infection. However, the activity of APS in anti-influenza virus has yet to be investigated. Here, we refined polysaccharides from A. vera leaf. In vitro test revealed that APS could inhibit the replication of a H1N1 subtype influenza virus, and the most obvious inhibitory effect was observed in the viral adsorption period. Transmission electron microscopy indicated that APS directly interacted with influenza virus particles. Experiments on PR8 (H1N1) virus infection in mice demonstrated that APS considerably ameliorated the clinical symptoms and the lung damage of the infected mice, and significantly reduced the virus loads and mortality. Our findings provided a theoretical basis for the development of novel natural anti-influenza agents.
KEYWORDS:
Aloe polysaccharides; H1N1; antivirus; transmission electron microscopy; viral adsorption
PMID: 30319596 PMCID: PMC6170609 DOI: 10.3389/fmicb.2018.02338
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Aloe Polysaccharides Inhibit Influenza A Virus Infection-A Promising Natural Anti-flu Drug.
Sun Z1, Yu C2, Wang W3, Yu G1, Zhang T1, Zhang L2, Zhang J1, Wei K2.
Author information
Abstract
Influenza A virus causes periodic outbreaks and seriously threatens human health. The drug-resistant mutants have shown an epidemic trend because of the abuse of chemical drugs. Aloe polysaccharides (APS) extracted from Aloe vera leaves have evident effects on the therapy of virus infection. However, the activity of APS in anti-influenza virus has yet to be investigated. Here, we refined polysaccharides from A. vera leaf. In vitro test revealed that APS could inhibit the replication of a H1N1 subtype influenza virus, and the most obvious inhibitory effect was observed in the viral adsorption period. Transmission electron microscopy indicated that APS directly interacted with influenza virus particles. Experiments on PR8 (H1N1) virus infection in mice demonstrated that APS considerably ameliorated the clinical symptoms and the lung damage of the infected mice, and significantly reduced the virus loads and mortality. Our findings provided a theoretical basis for the development of novel natural anti-influenza agents.
KEYWORDS:
Aloe polysaccharides; H1N1; antivirus; transmission electron microscopy; viral adsorption
PMID: 30319596 PMCID: PMC6170609 DOI: 10.3389/fmicb.2018.02338
Free full text