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Bioorg Med Chem Lett. 2018 Mar 30. pii: S0960-894X(18)30286-5. doi: 10.1016/j.bmcl.2018.03.080. [Epub ahead of print]
Secoiridoid analogues from the fruits of Ligustrum lucidum and their inhibitory activities against influenza A virus.
Pang X1, Zhao JY2, Yu HY1, Yu LY2, Wang T1, Zhang Y1, Gao XM3, Han LF4.
Author information
Abstract
A phytochemical study focusing on the secoiridoid components in the fruits of Ligustrum lucidum was carried out, which finally led to the isolation of nine secoiridoid glycosides (1-9) together with two secoiridoids (10, 11). The structures of all compounds were established mainly by NMR and MS experiments as well as the necessary chemical evidence, of which 1, 2, 4 (ligulucisides A-C), 10 and 11 (liguluciridoids A and B) were identified as new secoiridoid analogues. An in vitro antiviral bioassay indicated that 1, 4, 6, and 10 displayed the inhibitory activities against influenza A virus with the IC50 values of 16.5, 12.5, 13.1, and 18.5 μM, respectively, which were better than the positive control Ribavirin (IC50 22.6 μM). .
KEYWORDS:
Influenza A virus; Ligustrum lucidum; Oleaceae; Secoiridoid
PMID: 29625823 DOI: 10.1016/j.bmcl.2018.03.080
Secoiridoid analogues from the fruits of Ligustrum lucidum and their inhibitory activities against influenza A virus.
Pang X1, Zhao JY2, Yu HY1, Yu LY2, Wang T1, Zhang Y1, Gao XM3, Han LF4.
Author information
Abstract
A phytochemical study focusing on the secoiridoid components in the fruits of Ligustrum lucidum was carried out, which finally led to the isolation of nine secoiridoid glycosides (1-9) together with two secoiridoids (10, 11). The structures of all compounds were established mainly by NMR and MS experiments as well as the necessary chemical evidence, of which 1, 2, 4 (ligulucisides A-C), 10 and 11 (liguluciridoids A and B) were identified as new secoiridoid analogues. An in vitro antiviral bioassay indicated that 1, 4, 6, and 10 displayed the inhibitory activities against influenza A virus with the IC50 values of 16.5, 12.5, 13.1, and 18.5 μM, respectively, which were better than the positive control Ribavirin (IC50 22.6 μM). .
KEYWORDS:
Influenza A virus; Ligustrum lucidum; Oleaceae; Secoiridoid
PMID: 29625823 DOI: 10.1016/j.bmcl.2018.03.080