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Pediatr Infect Dis J. 2017 Sep 5. doi: 10.1097/INF.0000000000001775. [Epub ahead of print]
Antibiotic Use in Hospitalized Children with Respiratory Viruses Detected by Multiplex Polymerase Chain Reaction.
Goriacko P1, Saiman L, Zachariah P.
Author information
Abstract
BACKGROUND:
Multiplex polymerase chain reaction (mPCR) based methods are increasingly used to detect respiratory pathogens in children. While rapid identification of viruses has been shown to reduce antibiotic use, the impact of detecting specific viruses on antibiotic utilization has not been ascertained. This study compared antibiotic utilization among hospitalized children who tested positive for different respiratory viruses at admission.
METHODS:
A single-center study of hospitalized children under 21 years of age who tested positive at admission for at least one respiratory virus by mPCR from October 1 2012 to October 1 2015 was performed. Multivariable logistic regression was used to determine the association of testing positive for specific viruses with the use of antibiotics for ≥ 2 days, adjusted for demographic and clinical characteristics.
RESULTS:
The study included 1416 patients with a median age of 2.1 years (IQR 0.6-6.2 years). Patients positive for influenza (OR 2.0, 95% CI 1.1 - 3.4) and human metapneumovirus (HMPV) (OR 2.0, 95% CI 1.1-3.7) were more likely to receive ≥ 2 days of treatment compared to patients positive for respiratory syncytial virus (RSV). Other variables affecting prolonged use of antibiotics included respiratory support, primary non-respiratory diagnosis, complex comorbid conditions, and admission to the intensive care unit.
CONCLUSIONS:
Providers are more likely to use antibiotics in non-RSV infected patients compared to RSV. These trends likely represent concern about bacterial superinfection and may reflect lack of familiarity with these pathogens.
PMID: 28877158 DOI: 10.1097/INF.0000000000001775
Antibiotic Use in Hospitalized Children with Respiratory Viruses Detected by Multiplex Polymerase Chain Reaction.
Goriacko P1, Saiman L, Zachariah P.
Author information
Abstract
BACKGROUND:
Multiplex polymerase chain reaction (mPCR) based methods are increasingly used to detect respiratory pathogens in children. While rapid identification of viruses has been shown to reduce antibiotic use, the impact of detecting specific viruses on antibiotic utilization has not been ascertained. This study compared antibiotic utilization among hospitalized children who tested positive for different respiratory viruses at admission.
METHODS:
A single-center study of hospitalized children under 21 years of age who tested positive at admission for at least one respiratory virus by mPCR from October 1 2012 to October 1 2015 was performed. Multivariable logistic regression was used to determine the association of testing positive for specific viruses with the use of antibiotics for ≥ 2 days, adjusted for demographic and clinical characteristics.
RESULTS:
The study included 1416 patients with a median age of 2.1 years (IQR 0.6-6.2 years). Patients positive for influenza (OR 2.0, 95% CI 1.1 - 3.4) and human metapneumovirus (HMPV) (OR 2.0, 95% CI 1.1-3.7) were more likely to receive ≥ 2 days of treatment compared to patients positive for respiratory syncytial virus (RSV). Other variables affecting prolonged use of antibiotics included respiratory support, primary non-respiratory diagnosis, complex comorbid conditions, and admission to the intensive care unit.
CONCLUSIONS:
Providers are more likely to use antibiotics in non-RSV infected patients compared to RSV. These trends likely represent concern about bacterial superinfection and may reflect lack of familiarity with these pathogens.
PMID: 28877158 DOI: 10.1097/INF.0000000000001775