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Sialylglycan-Assembled Supra-dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses

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  • Sialylglycan-Assembled Supra-dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses

    ACS Appl Mater Interfaces. 2017 Jul 13. doi: 10.1021/acsami.7b07485. [Epub ahead of print]
    Sialylglycan-Assembled Supra-dots for Ratiometric Probing and Blocking of Human-Infecting Influenza Viruses.

    Wang CZ, Han HH, Tang XY, Zhou DM, Wu C, Chen GR, He XP, Tian H.
    Abstract

    The seasonal outbreak of influenza causes significant morbidity and mortality worldwide since a number of influenza virus (IV) strains have been shown to infect and circulate in hu-mans. Development of effective means to timely monitor as well as block IVs is still a chal-lenging task. While conventional fluorescence probes rely on a fluorimetric change upon rec-ognizing IVs, here we developed simple "Supra-dots" that are formed through the aqueous su-pramolecular assembly between a blue-emitting polymer dot and red-emitting sialylglycan probes for the ratiometric detection of IVs. Tuning the Förster resonance energy-transfer from polymer dots to glycan-probes by selective sialylglycan-virus recognition enables the fluores-cence ratiometric determination of IVs, whereas the presence of unselective, control viruses quenched the fluorescence of the Supra-dots. Meanwhile, we show that the Supra-dots can ef-fectively inhibit the invasion of a human-infecting IV towards a human cell line, thereby mak-ing possible a unique bifunctional, supramolecular probe for influenza theranostics.


    PMID: 28703004 DOI: 10.1021/acsami.7b07485
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