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J Pharm Pharmacol. 2016 Feb 21. doi: 10.1111/jphp.12529. [Epub ahead of print]
Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection.
Kim H1,2, Jang M1, Kim Y1, Choi J1, Jeon J1, Kim J3, Hwang YI1, Kang JS1,2, Lee WJ1.
Author information
Abstract
OBJECTIVES:
Because red ginseng and vitamin C have immunomodulatory function and anti-viral effect, we investigated whether red ginseng and vitamin C synergistically regulate immune cell function and suppress viral infection.
METHODS:
Red ginseng and vitamin C were treated to human peripheral blood mononuclear cells (PBMCs) or sarcoma-associated herpesvirus (KSHV)-infected BCBL-1, and administrated to Gulo(-/-) mice, which are incapable of synthesizing vitamin C, with or without influenza A virus/H1N1 infection.
KEY FINDINGS:
Red ginseng and vitamin C increased the expression of CD25 and CD69 of PBMCs and natural killer (NK) cells. Co-treatment of them decreased cell viability and lytic gene expression in BCBL-1. In Gulo(-/-) mice, red ginseng and vitamin C increased the expression of NKp46, a natural cytotoxic receptor of NK cells and interferon (IFN)-γ production. Influenza infection decreased the survival rate, and increased inflammation and viral plaque accumulation in the lungs of vitamin C-depleted Gulo(-/-) mice, which were remarkably reduced by red ginseng and vitamin C supplementation.
CONCLUSIONS:
Administration of red ginseng and vitamin C enhanced the activation of immune cells like T and NK cells, and repressed the progress of viral lytic cycle. It also reduced lung inflammation caused by viral infection, which consequently increased the survival rate.
? 2016 Royal Pharmaceutical Society, Journal of Pharmacy and Pharmacology.
KEYWORDS:
H1N1; influenza A virus; red ginseng; vitamin C
PMID: 26898166 [PubMed - as supplied by publisher]
Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection.
Kim H1,2, Jang M1, Kim Y1, Choi J1, Jeon J1, Kim J3, Hwang YI1, Kang JS1,2, Lee WJ1.
Author information
Abstract
OBJECTIVES:
Because red ginseng and vitamin C have immunomodulatory function and anti-viral effect, we investigated whether red ginseng and vitamin C synergistically regulate immune cell function and suppress viral infection.
METHODS:
Red ginseng and vitamin C were treated to human peripheral blood mononuclear cells (PBMCs) or sarcoma-associated herpesvirus (KSHV)-infected BCBL-1, and administrated to Gulo(-/-) mice, which are incapable of synthesizing vitamin C, with or without influenza A virus/H1N1 infection.
KEY FINDINGS:
Red ginseng and vitamin C increased the expression of CD25 and CD69 of PBMCs and natural killer (NK) cells. Co-treatment of them decreased cell viability and lytic gene expression in BCBL-1. In Gulo(-/-) mice, red ginseng and vitamin C increased the expression of NKp46, a natural cytotoxic receptor of NK cells and interferon (IFN)-γ production. Influenza infection decreased the survival rate, and increased inflammation and viral plaque accumulation in the lungs of vitamin C-depleted Gulo(-/-) mice, which were remarkably reduced by red ginseng and vitamin C supplementation.
CONCLUSIONS:
Administration of red ginseng and vitamin C enhanced the activation of immune cells like T and NK cells, and repressed the progress of viral lytic cycle. It also reduced lung inflammation caused by viral infection, which consequently increased the survival rate.
? 2016 Royal Pharmaceutical Society, Journal of Pharmacy and Pharmacology.
KEYWORDS:
H1N1; influenza A virus; red ginseng; vitamin C
PMID: 26898166 [PubMed - as supplied by publisher]