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Org Biomol Chem. 2015 Oct 14. [Epub ahead of print]
S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors.
Yeh HW1, Lin TS, Wang HW, Cheng HW, Liu DZ, Liang PH.
Author information
Abstract
An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 () and its 6-sulphate analogue has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener in both the virus neutralization assay and the hemagglutination inhibition assay.
PMID: 26464117 [PubMed - as supplied by publisher]
S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors.
Yeh HW1, Lin TS, Wang HW, Cheng HW, Liu DZ, Liang PH.
Author information
Abstract
An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 () and its 6-sulphate analogue has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener in both the virus neutralization assay and the hemagglutination inhibition assay.
PMID: 26464117 [PubMed - as supplied by publisher]