Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice

[tetano]

PLoS One. 2014 Jan 22;9(1):e86416. doi: 10.1371/journal.pone.0086416. eCollection 2014.

Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice.

Kikuchi Y1, Kunitoh-Asari A1, Hayakawa K1, Imai S2, Kasuya K3, Abe K4, Adachi Y5, Fukudome S1, Takahashi Y5, Hachimura S6.
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Abstract

The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA production by murine Peyer's patch cells. We selected one strain and named it Lactobacillus plantarum AYA. We found that L. plantarum AYA-induced production of IL-6 in Peyer's patch dendritic cells, with this production promoting IgA(+) B cells to differentiate into IgA-secreting plasma cells. We also observed that oral administration of L. plantarum AYA in mice caused an increase in IgA production in the small intestine and lung. This production of IgA correlated strongly with protective ability, with the treated mice surviving longer than the control mice after lethal influenza virus infection. Our data therefore reveals a novel immunoregulatory role of the L. plantarum AYA strain which enhances mucosal IgA production and provides protection against respiratory influenza virus infection.

PMID:
24466081
[PubMed - in process]

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http://www.ncbi.nlm.nih.gov/pubmed/24466081

[Gert van der Hoek]

Re: Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice

This is interesting. An important part of our immunesystem is in our gut: our gut bacteria.

Lactobacillus Plantarum is one of the bacteria which can pass through our gut and modulate the immunesystem. Apparently our body is adapted to or even needs to have input from bacteria from outside. As far as I know, L Plantarum doesn't colonize in the human gut, it is a lactic acid bacterium.

L Plantarum is known to help to get rid of eczema. You could try it: add some raw sauerkraut or kimchi to your daily menu.

Apparently L Plantarum may help to fight influenza by boosting your immune system.

See also:

Probiotics 'may stop pneumonia'

Apple Cider Vinegar with Mother may help cure Flu