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Bioorg Med Chem Lett. 2013 Dec 11. pii: S0960-894X(13)01368-1. doi: 10.1016/j.bmcl.2013.11.077. [Epub ahead of print]
Bifunctional thiosialosides inhibit influenza virus.
Yang Y1, He Y1, Li X1, Dinh H1, Iyer SS2.
Author information
Abstract
We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).
Copyright ? 2013 Elsevier Ltd. All rights reserved.
KEYWORDS:
Bifunctional, Glycoconjugates, Influenza virus, Inhibitors, Sialic acid
PMID:
24374271
[PubMed - as supplied by publisher]
Bifunctional thiosialosides inhibit influenza virus.
Yang Y1, He Y1, Li X1, Dinh H1, Iyer SS2.
Author information
Abstract
We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).
Copyright ? 2013 Elsevier Ltd. All rights reserved.
KEYWORDS:
Bifunctional, Glycoconjugates, Influenza virus, Inhibitors, Sialic acid
PMID:
24374271
[PubMed - as supplied by publisher]
