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Bioorg Med Chem Lett. 2013 Aug 17. pii: S0960-894X(13)00988-8. doi: 10.1016/j.bmcl.2013.08.048. [Epub ahead of print]
Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus.
Kessler U, Castagnolo D, Pagano M, Deodato D, Bernardini M, Pilger B, Ranadheera C, Botta M.
Source
PiKe Pharma GmbH, Zurich, Switzerland.
Abstract
The identification of a novel hit compound inhibitor of the protein-protein interaction between the influenza RNA-polymerase PA and PB1 subunits has been accomplished by means of high-throughput screening. A small family of structurally related molecules has been synthesized and biologically evaluated with most of the compounds showing micromolar potency of inhibition against viral replication.
Copyright ? 2013. Published by Elsevier Ltd.
KEYWORDS:
Antiviral agents, Benzofurazan, H1N1, Influenza virus, Viral RNA polymerase
PMID:
24012120
[PubMed - as supplied by publisher]
Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus.
Kessler U, Castagnolo D, Pagano M, Deodato D, Bernardini M, Pilger B, Ranadheera C, Botta M.
Source
PiKe Pharma GmbH, Zurich, Switzerland.
Abstract
The identification of a novel hit compound inhibitor of the protein-protein interaction between the influenza RNA-polymerase PA and PB1 subunits has been accomplished by means of high-throughput screening. A small family of structurally related molecules has been synthesized and biologically evaluated with most of the compounds showing micromolar potency of inhibition against viral replication.
Copyright ? 2013. Published by Elsevier Ltd.
KEYWORDS:
Antiviral agents, Benzofurazan, H1N1, Influenza virus, Viral RNA polymerase
PMID:
24012120
[PubMed - as supplied by publisher]
