Aminoglycoside Antibiotics Bind to the Influenza A Virus RNA Promoter

[tetano]

Molecular BioSystems
Communication
Aminoglycoside Antibiotics Bind to the Influenza A Virus RNA Promoter
Henna Kim , Mi-Kyung Lee , Junsang Ko , Chin-Ju Park , Meehyein Kim , Yujeong Jeong , Sungwoo Hong , Gabriele Varani and Byong-Seok Choi
Mol. BioSyst., 2012, Accepted Manuscript

DOI: 10.1039/C2MB25333J
Received 14 Aug 2012, Accepted 07 Sep 2012
First published on the web 12 Sep 2012

Aminoglycosides bind to the influenza A virus promoter (vRNA) at submicromolar concentration. The complex structure between the vRNA and neomycin illustrates that binding of neomycin causes a conformational change which would affect further transcription processes. Thus, aminoglycosides represent lead compounds for the discovery of antiviral therapeutics against influenza A virus.

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