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J Infect
. 2024 Sep 26:106292.
doi: 10.1016/j.jinf.2024.106292. Online ahead of print. Severity of Respiratory Syncytial Virus compared with SARS-CoV-2 and Influenza among hospitalised adults ≥65 years
Lorena Vega-Piris 1 , Silvia Galindo Carretero 2 , José Luis Mayordomo 3 , Mercedes Belén Rumayor Zarzuelo 4 , Virginia Álvarez Río 5 , Virtudes Gallardo García 6 , Miriam García Vázquez 7 , María Del Carmen García Rodríguez 8 , Luca Basile 9 , Nieves López González-Coviella 10 , Maria Isabel Barranco Boada 11 , Olaia Pérez-Martínez 12 , Ana Lameiras Azevedo 13 , Carmen Quiñones Rubio 14 , Jaume Giménez Duran 15 , Ana Fernández Ibáñez 16 , María Victoria García Rivera 17 , Violeta Ramos Marín 18 , Daniel Castrillejo 19 , Luis Javier Viloria Raymundo 20 , Amparo Larrauri 21 , Susana Monge 22 ; SARI Sentinel Surveillance Group
Affiliations
Introduction: Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19.
Methods: We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged ≥65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2.
Results: Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR=0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81(0.67-0.98)], ICU admission [vs. influenza: 0.93(0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64(0.32-1.28); vs. SARS-CoV-2: 0.56(0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARS-CoV-2: 1.83 (1.02-3.28)] CONCLUSIONS: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination.
Keywords: ICU admission; SARS-CoV2; influenza; mortality; pneumonia; severe acute respiratory infection; syncytial respiratory virus; vaccination.
. 2024 Sep 26:106292.
doi: 10.1016/j.jinf.2024.106292. Online ahead of print. Severity of Respiratory Syncytial Virus compared with SARS-CoV-2 and Influenza among hospitalised adults ≥65 years
Lorena Vega-Piris 1 , Silvia Galindo Carretero 2 , José Luis Mayordomo 3 , Mercedes Belén Rumayor Zarzuelo 4 , Virginia Álvarez Río 5 , Virtudes Gallardo García 6 , Miriam García Vázquez 7 , María Del Carmen García Rodríguez 8 , Luca Basile 9 , Nieves López González-Coviella 10 , Maria Isabel Barranco Boada 11 , Olaia Pérez-Martínez 12 , Ana Lameiras Azevedo 13 , Carmen Quiñones Rubio 14 , Jaume Giménez Duran 15 , Ana Fernández Ibáñez 16 , María Victoria García Rivera 17 , Violeta Ramos Marín 18 , Daniel Castrillejo 19 , Luis Javier Viloria Raymundo 20 , Amparo Larrauri 21 , Susana Monge 22 ; SARI Sentinel Surveillance Group
Affiliations
- PMID: 39341402
- DOI: 10.1016/j.jinf.2024.106292
Introduction: Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19.
Methods: We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged ≥65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2.
Results: Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR=0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81(0.67-0.98)], ICU admission [vs. influenza: 0.93(0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64(0.32-1.28); vs. SARS-CoV-2: 0.56(0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARS-CoV-2: 1.83 (1.02-3.28)] CONCLUSIONS: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination.
Keywords: ICU admission; SARS-CoV2; influenza; mortality; pneumonia; severe acute respiratory infection; syncytial respiratory virus; vaccination.