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Virology
. 2024 May 28:596:110124.
doi: 10.1016/j.virol.2024.110124. Online ahead of print. Infection dynamics of subtype H9N2 low pathogenic avian influenza a virus in turkeys
Mariette F Ducatez 1 , Chengcheng Wang 2 , Jialiang Yang 3 , Yulong Zhao 3 , Charlotte Foret-Lucas 4 , Guillaume Croville 4 , Josianne Loupias 4 , Angélique Teillaud 4 , Brigitte Peralta 4 , Abdeljelil Ghram 5 , Jean-Luc Guérin 4 , Xiu-Feng Wan 6
Affiliations
While mammals can be infected by influenza A virus either sporadically or with well adapted lineages, aquatic birds are the natural reservoir of the pathogen. So far most of the knowledge on influenza virus dynamics was however gained on mammalian models. In this study, we infected turkeys using a low pathogenic avian influenza virus and determined the infection dynamics with a target-cell limited model. Results showed that turkeys had a different set of infection characteristics, compared with humans and ponies. The viral clearance rates were similar between turkeys and ponies but higher than that in humans. The cell death rates and cell to cell transmission rates were similar between turkeys and humans but higher than those in ponies. Overall, this study indicated the variations of within-host dynamics of influenza infection in avian, humans, and other mammalian systems.
Keywords: Chicken; Infection dynamics; Influenza virus; SIR; Target cell limited model.
. 2024 May 28:596:110124.
doi: 10.1016/j.virol.2024.110124. Online ahead of print. Infection dynamics of subtype H9N2 low pathogenic avian influenza a virus in turkeys
Mariette F Ducatez 1 , Chengcheng Wang 2 , Jialiang Yang 3 , Yulong Zhao 3 , Charlotte Foret-Lucas 4 , Guillaume Croville 4 , Josianne Loupias 4 , Angélique Teillaud 4 , Brigitte Peralta 4 , Abdeljelil Ghram 5 , Jean-Luc Guérin 4 , Xiu-Feng Wan 6
Affiliations
- PMID: 38838475
- DOI: 10.1016/j.virol.2024.110124
While mammals can be infected by influenza A virus either sporadically or with well adapted lineages, aquatic birds are the natural reservoir of the pathogen. So far most of the knowledge on influenza virus dynamics was however gained on mammalian models. In this study, we infected turkeys using a low pathogenic avian influenza virus and determined the infection dynamics with a target-cell limited model. Results showed that turkeys had a different set of infection characteristics, compared with humans and ponies. The viral clearance rates were similar between turkeys and ponies but higher than that in humans. The cell death rates and cell to cell transmission rates were similar between turkeys and humans but higher than those in ponies. Overall, this study indicated the variations of within-host dynamics of influenza infection in avian, humans, and other mammalian systems.
Keywords: Chicken; Infection dynamics; Influenza virus; SIR; Target cell limited model.