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Nat Commun
. 2024 May 27;15(1):4500.
doi: 10.1038/s41467-024-48934-6. Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level
Susanne Kessler # 1 2 , Bradly Burke # 3 , Geoffroy Andrieux 2 4 , Jan Schinköthe 5 , Lea Hamberger 1 2 , Johannes Kacza 6 , Shijun Zhan 3 , Clara Reasoner 3 , Taru S Dutt 7 , Maria Kaukab Osman 1 2 8 9 , Marcela Henao-Tamayo 7 , Julian Staniek 9 10 11 , Jose Francisco Villena Ossa 11 12 , Dalit T Frank 3 , Wenjun Ma 13 , Reiner Ulrich 5 , Toni Cathomen 2 11 12 , Melanie Boerries 2 4 14 , Marta Rizzi 10 11 15 16 , Martin Beer 17 , Martin Schwemmle 1 2 , Peter Reuther 1 2 , Tony Schountz 18 , Kevin Ciminski 19 20
Affiliations
Jamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human relevance. These infections are typically mild in bats, suggesting unique features of their immune system. To better understand the immune response to viral infections in bats, we infected male Jamaican fruit bats with the bat-derived influenza A virus (IAV) H18N11. Using comparative single-cell RNA sequencing, we generated single-cell atlases of the Jamaican fruit bat intestine and mesentery. Gene expression profiling showed that H18N11 infection resulted in a moderate induction of interferon-stimulated genes and transcriptional activation of immune cells. H18N11 infection was predominant in various leukocytes, including macrophages, B cells, and NK/T cells. Confirming these findings, human leukocytes, particularly macrophages, were also susceptible to H18N11, highlighting the zoonotic potential of this bat-derived IAV. Our study provides insight into a natural virus-host relationship and thus serves as a fundamental resource for future in-depth characterization of bat immunology.
. 2024 May 27;15(1):4500.
doi: 10.1038/s41467-024-48934-6. Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level
Susanne Kessler # 1 2 , Bradly Burke # 3 , Geoffroy Andrieux 2 4 , Jan Schinköthe 5 , Lea Hamberger 1 2 , Johannes Kacza 6 , Shijun Zhan 3 , Clara Reasoner 3 , Taru S Dutt 7 , Maria Kaukab Osman 1 2 8 9 , Marcela Henao-Tamayo 7 , Julian Staniek 9 10 11 , Jose Francisco Villena Ossa 11 12 , Dalit T Frank 3 , Wenjun Ma 13 , Reiner Ulrich 5 , Toni Cathomen 2 11 12 , Melanie Boerries 2 4 14 , Marta Rizzi 10 11 15 16 , Martin Beer 17 , Martin Schwemmle 1 2 , Peter Reuther 1 2 , Tony Schountz 18 , Kevin Ciminski 19 20
Affiliations
- PMID: 38802391
- DOI: 10.1038/s41467-024-48934-6
Jamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human relevance. These infections are typically mild in bats, suggesting unique features of their immune system. To better understand the immune response to viral infections in bats, we infected male Jamaican fruit bats with the bat-derived influenza A virus (IAV) H18N11. Using comparative single-cell RNA sequencing, we generated single-cell atlases of the Jamaican fruit bat intestine and mesentery. Gene expression profiling showed that H18N11 infection resulted in a moderate induction of interferon-stimulated genes and transcriptional activation of immune cells. H18N11 infection was predominant in various leukocytes, including macrophages, B cells, and NK/T cells. Confirming these findings, human leukocytes, particularly macrophages, were also susceptible to H18N11, highlighting the zoonotic potential of this bat-derived IAV. Our study provides insight into a natural virus-host relationship and thus serves as a fundamental resource for future in-depth characterization of bat immunology.