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Emerg Infect Dis
. 2023 Jul;29(7):1397-1406.
doi: 10.3201/eid2907.230165.
Long-Term Epidemiology and Evolution of Swine Influenza Viruses, Vietnam
Jonathan Cheung, Anh Ngoc Bui, Sonia Younas, Kimberly M Edwards, Huy Quang Nguyen, Ngoc Thi Pham, Vuong Nghia Bui, Malik Peiris, Vijaykrishna Dhanasekaran
Influenza A viruses are a One Health threat because they can spill over between host populations, including among humans, swine, and birds. Surveillance of swine influenza virus in Hanoi, Vietnam, during 2013-2019 revealed gene pool enrichment from imported swine from Asia and North America and showed long-term maintenance, persistence, and reassortment of virus lineages. Genome sequencing showed continuous enrichment of H1 and H3 diversity through repeat introduction of human virus variants and swine influenza viruses endemic in other countries. In particular, the North American H1-δ1a strain, which has a triple-reassortant backbone that potentially results in increased human adaptation, emerged as a virus that could pose a zoonotic threat. Co-circulation of H1-δ1a viruses with other swine influenza virus genotypes raises concerns for both human and animal health.
Keywords: H1-δ1a virus; Swine influenza virus; Vietnam; epidemiology; genome sequencing; influenza; phylogenetics; reassortment; respiratory infections; risk assessment; serological surveillance; virological surveillance; viruses; zoonoses.
. 2023 Jul;29(7):1397-1406.
doi: 10.3201/eid2907.230165.
Long-Term Epidemiology and Evolution of Swine Influenza Viruses, Vietnam
Jonathan Cheung, Anh Ngoc Bui, Sonia Younas, Kimberly M Edwards, Huy Quang Nguyen, Ngoc Thi Pham, Vuong Nghia Bui, Malik Peiris, Vijaykrishna Dhanasekaran
- PMID: 37347532
- DOI: 10.3201/eid2907.230165
Influenza A viruses are a One Health threat because they can spill over between host populations, including among humans, swine, and birds. Surveillance of swine influenza virus in Hanoi, Vietnam, during 2013-2019 revealed gene pool enrichment from imported swine from Asia and North America and showed long-term maintenance, persistence, and reassortment of virus lineages. Genome sequencing showed continuous enrichment of H1 and H3 diversity through repeat introduction of human virus variants and swine influenza viruses endemic in other countries. In particular, the North American H1-δ1a strain, which has a triple-reassortant backbone that potentially results in increased human adaptation, emerged as a virus that could pose a zoonotic threat. Co-circulation of H1-δ1a viruses with other swine influenza virus genotypes raises concerns for both human and animal health.
Keywords: H1-δ1a virus; Swine influenza virus; Vietnam; epidemiology; genome sequencing; influenza; phylogenetics; reassortment; respiratory infections; risk assessment; serological surveillance; virological surveillance; viruses; zoonoses.