Lancet Microbe . H9N2 avian influenza viruses: challenges and the way forward

[tetano]

Lancet Microbe


. 2022 Nov 10;S2666-5247(22)00305-6.
doi: 10.1016/S2666-5247(22)00305-6. Online ahead of print.
H9N2 avian influenza viruses: challenges and the way forward


Jiahao Zhang ¹ , Lihong Huang ¹ , Ming Liao ² , Wenbao Qi ³



Affiliations

• PMID: 36372076
• DOI: 10.1016/S2666-5247(22)00305-6

No abstract available

Conflict of interest statement

We declare no competing interests. We acknowledge the authors, originating and submitting laboratories of the sequences from the Global Initiative on Sharing All Influenza Data (GISAID)'s EpiFlu Database on which this research is based. All submitters of data can be contacted directly through the GISAID website (www.gisaid.org). This Correspondence was supported by National Natural Science Foundation of China (grant numbers 31830097 and 31672586), and Young Scholars of Yangtze River Scholar Professor Program (2019 WQ). JZ, ML, and WQ planned and conceptualised the laboratory work, and wrote the Correspondence. JZ and LH conducted the virus isolation from samples, antigenic analysis, animal experiments, and sequenced the genomes. ML and WQ provided the funding.

[sharon sanders]

hat tip @ButlerJohnW for an added emphasis on lack of vaccine efficacy in H9N2 vaccines

snip

Therefore, the antigenic mutations of H9N2 viruses should also be taken into consideration when choosing the vaccine strains. The pandemic potential of H9N2 viruses is shown by the constant emergence of human-infecting influenza viruses with the internal genes of H9N2,² demonstrating that stopping the generation of novel human-infecting avian influenza viruses at their origin is urgently needed. We strongly advise that more attention be given to the prevention and control of H9N2 viruses, not only to enhance the ongoing H9N2 surveillance of birds and high-density at-risk human populations, but also to develop universal H9N2 vaccines.

https://www.thelancet.com/journals/l...305-6/fulltext