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Antimicrob Resist Infect Control
. 2022 Feb 8;11(1):31.
doi: 10.1186/s13756-021-01046-y.
Effect of a multimodal strategy for prevention of nosocomial influenza: a retrospective study at Grenoble Alpes University Hospital from 2014 to 2019
Meghann Gallouche 1 2 , Hugo Terrisse 1 , Sylvie Larrat 3 , Sylvie Marfaing 4 , Christelle Di Cioccio 5 , Bruno Verit 5 , Patrice Morand 3 6 , Vincent Bonneterre 5 7 , Jean-Luc Bosson 1 8 , Caroline Landelle 9 10
Affiliations
- PMID: 35135618
- PMCID: PMC8822851
- DOI: 10.1186/s13756-021-01046-y
Abstract
Background: A multimodal strategy to prevent nosocomial influenza was implemented in 2015-2016 in Grenoble Alpes University Hospital. Three modalities were implemented in all units: promotion of vaccination among healthcare workers, epidemiologic surveillance and communication campaigns. Units receiving a high number of patients with influenza implemented 2 additional modalities: improvement of diagnosis capacities and systematic surgical mask use. The main objective was to assess the effectiveness of the strategy for reducing the risk of nosocomial influenza.
Methods: A study was conducted retrospectively investigating 5 epidemic seasons (2014-2015 to 2018-2019) including all patients hospitalized with a positive influenza test at Grenoble Alpes University Hospital. The weekly number of nosocomial influenza cases was analyzed by Poisson regression and incidence rate ratios (IRR) were estimated.
Results: A total of 1540 patients, resulting in 1559 stays, were included. There was no significant difference between the 5 influenza epidemic seasons in the units implementing only 3 measures. In the units implementing the 5 measures, there was a reduction of nosocomial influenza over the seasons when the strategy was implemented compared to the 2014-2015 epidemic season (IRR = 0.56, 95% CI = 0.23-1.34 in 2015-2016; IRR = 0.39, 95% CI = 0.19-0.81 in 2016-2017; IRR = 0.50, 95% CI = 0.24-1.03 in 2017-2018; IRR = 0.48, 95% CI = 0.23-0.97 in 2018-2019).
Conclusions: Our data mainly suggested that the application of the strategy with 5 modalities, including systematic surgical mask use and rapid diagnosis, seemed to reduce by half the risk of nosocomial influenza. Further data, including medico-economic studies, are necessary to determine the opportunity of extending these measures at a larger scale.
Keywords: Healthcare-associated infection; Infection control; Multimodal strategy; Nosocomial influenza; Prevention.